神經(jīng)生長(cháng)相關(guān)蛋白43單克隆抗體

產(chǎn)品貨號：

BN42010M
中文名稱(chēng)：

神經(jīng)生長(cháng)相關(guān)蛋白43單克隆抗體
英文名稱(chēng)：

Mouse anti-GAP43 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN42010M-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF
BN42010M-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF

產(chǎn)品描述

英文名稱(chēng)	GAP43
中文名稱(chēng)	神經(jīng)生長(cháng)相關(guān)蛋白43單克隆抗體
別名	Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.
研究領(lǐng)域	腫瘤免疫學(xué) 神經(jīng)生物學(xué)
抗體來(lái)源	Mouse
克隆類(lèi)型	Monoclonal
克隆號	6F11
交叉反應	Mouse, Rat, (predicted: Human, )
產(chǎn)品應用	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	43kDa
細胞定位	細胞漿細胞膜分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human GAP43 Protein:
亞型	IgG
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Subunit: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Subcellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. Post-translational modifications: Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity. Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2. Similarity: Belongs to the neuromodulin family. Contains 1 IQ domain. SWISS: P17677 Gene ID: 2596 Database links: Entrez Gene: 2596 Human Entrez Gene: 14432 Mouse Entrez Gene: 29423 Rat GenBank: NP_002036 Human Omim: 162060 Human SwissProt: P17677 Human SwissProt: P06837 Mouse SwissProt: P07936 Rat Unigene: 134974 Human Unigene: 1222 Mouse Unigene: 10928 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology）；神經(jīng)標志物 GAP43 （Growth associated protein-43）又稱(chēng)作neuromodulin，是一個(gè)軸突膜蛋白，是一種神經(jīng)特異性的蛋白質(zhì)，參與神經(jīng)細胞外生長(cháng)及突觸發(fā)育形成和神經(jīng)細胞再生。在神經(jīng)元發(fā)育和再生過(guò)程中以高水平表達。能調解軸突延伸作用，改變細胞形態(tài)。作為細胞內信號，可大大增強與G蛋白偶聯(lián)的受體轉運作用。神經(jīng)生長(cháng)相關(guān)蛋白-GAP-43和神經(jīng)細胞黏附因子(neural cell adhesion molecule,NCAM)與突觸可塑性密切相關(guān).GAP-43是一種神經(jīng)細胞膜上的特異性磷蛋白,在神經(jīng)發(fā)育和再生過(guò)程中呈現高表達,被作為突觸生長(cháng)的標志物,有稱(chēng)脊髓生長(cháng)相關(guān)蛋白 GAP-43與CaM結合,參與G蛋白相互作用,神經(jīng)遞質(zhì)的釋放,作用于胞吞/胞吐過(guò)程,通過(guò)小囊溶合或誘導生長(cháng)錐和突觸前末端的胞吞促進(jìn)膜擴展,與海馬長(cháng)時(shí)程增強密切相關(guān). 神經(jīng)細胞黏附因子是細胞表面糖蛋白大家族的成員之一,促進(jìn)軸突生長(cháng),對長(cháng)時(shí)記憶的保持有重要影響,同時(shí),GAP-43對其具調節作用，廣泛而深入地研究GAP-43意義深遠。