熱休克蛋白90β/HSP90 β 單克隆抗體

產(chǎn)品貨號：

BN42001M
中文名稱(chēng)：

熱休克蛋白90β/HSP90 β 單克隆抗體
英文名稱(chēng)：

Mouse anti-HSP90 beta Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN42001M-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rat 推薦應用：WB
BN42001M-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat 推薦應用：WB

產(chǎn)品描述

英文名稱(chēng)	HSP90 beta
中文名稱(chēng)	熱休克蛋白90β/HSP90 β 單克隆抗體
別名	HSP90 beta; D6S182; FLJ26984; Heat shock 90kD protein 1, beta; Heat shock protein 90kDa alpha (cytosolic) class B member 1; Heat shock protein beta; Heat shock protein HSP 90 beta; HSP 84; HSP84; HSP 90; HSP-90 BETA; HSP90B; HSPC2; HSPCB; HS90B_HUMAN; Heat shock protein HSP 90-beta; Heat shock 84 kDa.
研究領(lǐng)域	腫瘤免疫學(xué) 信號轉導轉錄調節因子
抗體來(lái)源	Mouse
克隆類(lèi)型	Monoclonal
克隆號	2A2
交叉反應	Human, Mouse, Rat,
產(chǎn)品應用	WB=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	84kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human HSP90 beta:
亞型	IgG
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]. Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Subunit: Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Subcellular Location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Post-translational modifications: Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro). ISGylated. S-nitrosylated; negatively regulates the ATPase activity (Probable). Similarity: Belongs to the heat shock protein 90 family. SWISS: P08238 Gene ID: 3326 Database links: Entrez Gene: 3326 Human Entrez Gene: 15516 Mouse Entrez Gene: 301252 Rat Omim: 140572 Human SwissProt: P08238 Human SwissProt: P11499 Mouse SwissProt: P34058 Rat Unigene: 509736 Human Unigene: 2180 Mouse Unigene: 98667 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. HSP是細胞受應激原刺激后誘導產(chǎn)生的一組應激蛋白，與腫瘤發(fā)生、增殖及分化有關(guān)，HSP90β能夠抑制細胞凋亡與分化。