• <li id="mmmm8"></li>
  • <noscript id="mmmm8"></noscript>
  • <tt id="mmmm8"></tt>
  • 最近搜索:細胞培養 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>8-羥基鳥(niǎo)嘌呤DNA糖基化酶
    8-羥基鳥(niǎo)嘌呤DNA糖基化酶
    • 產(chǎn)品貨號:
      BN41874R
    • 中文名稱(chēng):
      8-羥基鳥(niǎo)嘌呤DNA糖基化酶
    • 英文名稱(chēng):
      Rabbit anti-OGG1 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN41874R-50ul

      50ul

      ¥1486.00

      交叉反應:Rat,Mouse,Human(predicted:Cow,Pig,Dog) 推薦應用:WB,IHC-P,IHC-F,ELISA

    • BN41874R-100ul

      100ul

      ¥2360.00

      交叉反應:Rat,Mouse,Human(predicted:Cow,Pig,Dog) 推薦應用:WB,IHC-P,IHC-F,ELISA

    • BN41874R-200ul

      200ul

      ¥3490.00

      交叉反應:Rat,Mouse,Human(predicted:Cow,Pig,Dog) 推薦應用:WB,IHC-P,IHC-F,ELISA

    產(chǎn)品描述

    英文名稱(chēng)OGG1
    中文名稱(chēng)8-羥基鳥(niǎo)嘌呤DNA糖基化酶
    別    名8 hydroxyguanine DNA glycosylase; 8 oxoguanine DNA glycosylase 1; 8-oxoguanine DNA glycosylase; AP lyase; DNA apurinic or apyrimidinic site lyase; DNA lyase; DNA-(apurinic or apyrimidinic site) lyase; HMMH; HOGG 1; HOGG1; MMH; MUTM; N-glycosylase; Ogg 1; OGH 1; OGH1; OGG1_HUMAN.  



    研究領(lǐng)域細胞生物  免疫學(xué)  染色質(zhì)和核信號  線(xiàn)粒體  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, )
    產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量38-47kDa
    細胞定位細胞核 細胞漿 線(xiàn)粒體
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human OGG1/8 hydroxyguanine DNA glycosylase:151-250/424 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].

    Function:
    DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

    Subcellular Location:
    Mitochondrion; Nucleus and Nucleus > nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.

    Tissue Specificity:
    Ubiquitous.

    DISEASE:
    Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.

    Similarity:
    Belongs to the type-1 OGG1 family.

    SWISS:
    O15527

    Gene ID:
    4968

    Database links:

    Entrez Gene: 4968 Human

    Entrez Gene: 18294 Mouse

    Omim: 601982 Human

    SwissProt: O15527 Human

    SwissProt: O08760 Mouse

    Unigene: 380271 Human

    Unigene: 43612 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


    99久久精品费精品国产一区二区,色黄性日韩在线,天天操夜夜操,成人试看120秒体验区