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    • 最近搜索：細胞培養 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>泛素蛋白連接酶抗體
    泛素蛋白連接酶抗體
    • 產(chǎn)品貨號：
      BN41837R
    • 中文名稱(chēng)：
      泛素蛋白連接酶抗體
    • 英文名稱(chēng)：
      Rabbit anti-Fbx32 Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN41837R-50ul

      50ul

      ￥1486.00

      交叉反應：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41837R-100ul

      100ul

      ￥2360.00

      交叉反應：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41837R-200ul

      200ul

      ￥3490.00

      交叉反應：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱(chēng)Fbx32
    中文名稱(chēng)泛素蛋白連接酶抗體
    別    名Fbx32; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein.  



    研究領(lǐng)域細胞生物  干細胞  泛素  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
    產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量42kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human MAFbx:31-130/355 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.

    Function:
    Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

    Subunit:
    Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.

    Subcellular Location:
    Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus.

    Tissue Specificity:
    Specifically expressed in cardiac and skeletal muscle.

    Similarity:
    Contains 1 F-box domain.

    SWISS:
    Q969P5

    Gene ID:
    114907

    Database links:

    Entrez Gene: 513776 Cow

    Entrez Gene: 114907 Human

    Entrez Gene: 67731 Mouse

    Entrez Gene: Q2KHT6 Pig

    Entrez Gene: 171043 Rat

    Omim: 606604 Human

    SwissProt: Q2KHT6 Cow

    SwissProt: Q969P5 Human

    SwissProt: Q9CPU7 Mouse

    SwissProt: Q1A730 Pig

    SwissProt: Q91Z62 Rat

    Unigene: 403933 Human

    Unigene: 292042 Mouse

    Unigene: 72619 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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