細胞毒性受體NK-p46抗體

產(chǎn)品貨號：

BN41809R
中文名稱(chēng)：

細胞毒性受體NK-p46抗體
英文名稱(chēng)：

Rabbit anti-NCR1 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN41809R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41809R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41809R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱(chēng)	NCR1
中文名稱(chēng)	細胞毒性受體NK-p46抗體
別名	Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN.
研究領(lǐng)域	腫瘤
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Human, Mouse,
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	31kDa
細胞定位	細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human NCR1:1-100/304 <Extracellular>
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Subunit: Interacts with CD247 and FCER1G. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed by both resting and activated NK cells. Similarity: Belongs to the natural cytotoxicity receptor (NCR) family. Contains 2 Ig-like (immunoglobulin-like) domains. SWISS: O76036 Gene ID: 9437 Database links: Entrez Gene: 9437 Human Entrez Gene: 17086 Mouse Entrez Gene: 117547 Rat Omim: 604530 Human SwissProt: O76036 Human SwissProt: Q8C567 Mouse SwissProt: Q9Z0H5 Rat Unigene: 97084 Human Unigene: 240231 Mouse Unigene: 30049 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. NKp46是很重要的的自然細胞毒受體，在自然殺傷作用中起關(guān)鍵作用。細胞毒性受體家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表達于所有靜止和活化的NK細胞，而NKp44則選擇性的表達于活化的NK細胞。靶細胞上的配體分子與NCRs的結合（交聯(lián)）引發(fā)NK細胞的活化導致靶細胞的裂解和大量細胞因子的產(chǎn)生?，F已確認NKp46和NKp44可以識別病毒上的配體分子紅血球凝聚素，而NKp46則能識別腫瘤細胞上的乙酰硫酸多聚糖。