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產(chǎn)品規格
售價(jià)
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BN41679R-50ul
50ul
￥1486.00
交叉反應：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41679R-100ul
100ul
￥2360.00
交叉反應：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41679R-200ul
200ul
￥3490.00
交叉反應：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱(chēng) | GDF8 |
| 中文名稱(chēng) | 生長(cháng)分化因子8抗體 |
| 別 名 | GDF 8; GDF-8; GDF8_HUMAN; Growth differentiation factor 8; Growth/Differentiation Factor 8; MSTN; myostatin; OTTHUMP00000163498. |
| 研究領(lǐng)域 | 免疫學(xué) 生長(cháng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Chicken, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12/43kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GDF8:281-375/375 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. Acts specifically as a negative regulator of skeletal muscle growth. [SUBUNIT] Homodimer; [TISSUE SPECIFICITY] Expressed specifically in developing and adult skeletal muscle. Weak expression in adipose tissue. Belongs to the TGF-beta family. Function: Acts specifically as a negative regulator of skeletal muscle growth. Subunit: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3. Subcellular Location: Secreted Tissue Specificity: Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the adult, highest expression is seen in the gastrointestinal tract, brain, muscle, heart and testis. Also expressed in the adult pharynx, kidney, spleen, liver, gill, eyes, skin, swim bladder and ovary. DISEASE: Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Similarity: Belongs to the TGF-beta family. SWISS: O14793 Gene ID: 2660 Database links: Entrez Gene: 2660 Human Entrez Gene: 17700 Mouse Entrez Gene: 373964 Chicken Entrez Gene: 798441 Zebrafish Omim: 601788 Human SwissProt: O14793 Human SwissProt: O08689 Mouse SwissProt: O18830 Sheep SwissProt: O42222 Zebrafish Unigene: 41565 Human Unigene: 3514 Mouse Unigene: 44460 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GDF-8又稱(chēng)MSTN,是轉化生長(cháng)因子超家族，也是近年來(lái)發(fā)現的一類(lèi)重要的肌細胞生長(cháng)調控因子，它通過(guò)抑制MyoD家族成員轉錄活性負向控制肌細胞的生長(cháng)發(fā)育，它的表達量與肌肉重量的變化呈負相關(guān)。 |
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