• <li id="mmmm8"></li>
  • <noscript id="mmmm8"></noscript>
    • <tt id="mmmm8"></tt>
    • 最近搜索：細胞培養 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>細胞分裂周期蛋白25C抗體
    細胞分裂周期蛋白25C抗體
    • 產(chǎn)品貨號：
      BN41640R
    • 中文名稱(chēng)：
      細胞分裂周期蛋白25C抗體
    • 英文名稱(chēng)：
      Rabbit anti-Cdc25C Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN41640R-50ul

      50ul

      ￥1486.00

      交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

    • BN41640R-100ul

      100ul

      ￥2360.00

      交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

    • BN41640R-200ul

      200ul

      ￥3490.00

      交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

    產(chǎn)品描述

    英文名稱(chēng)Cdc25C
    中文名稱(chēng)細胞分裂周期蛋白25C抗體
    別    名CDC 25; Cdc 25C; CDC25; Cell division cycle 25 homolog C; Cell division cycle 25C; Cell division cycle 25C protein; Dual specificity phosphatase Cdc25C; M phase inducer phosphatase 3; Mitosis inducer CDC25; MPIP3; Phosphotyrosine phosphatase; MPIP3_HUMAN.  



    研究領(lǐng)域信號轉導  細胞周期蛋白  激酶和磷酸酶  表觀(guān)遺傳學(xué)  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, )
    產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量53kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Cdc25C:321-420/473 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]

    Function:
    Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.

    Subunit:
    Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity. Interacts with MAPK14 and 14-3-3 proteins.

    Subcellular Location:
    Nucleus.

    Post-translational modifications:
    Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.

    Similarity:
    Belongs to the MPI phosphatase family.
    Contains 1 rhodanese domain.

    SWISS:
    P30307

    Gene ID:
    995

    Database links:

    Entrez Gene: 995 Human

    Omim: 157680 Human

    SwissProt: P30307 Human

    Unigene: 656 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


    99久久精品费精品国产一区二区,色黄性日韩在线,天天操夜夜操,成人试看120秒体验区