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    • 最近搜索：細胞培養 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>神經(jīng)粘蛋白抗體
    神經(jīng)粘蛋白抗體
    • 產(chǎn)品貨號：
      BN41638R
    • 中文名稱(chēng)：
      神經(jīng)粘蛋白抗體
    • 英文名稱(chēng)：
      Rabbit anti-Neurocan Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN41638R-50ul

      50ul

      ￥1486.00

      交叉反應：Human,Mouse,Rat 推薦應用：IHC-P,IHC-F,IF,ELISA

    • BN41638R-100ul

      100ul

      ￥2360.00

      交叉反應：Human,Mouse,Rat 推薦應用：IHC-P,IHC-F,IF,ELISA

    • BN41638R-200ul

      200ul

      ￥3490.00

      交叉反應：Human,Mouse,Rat 推薦應用：IHC-P,IHC-F,IF,ELISA

    產(chǎn)品描述

    英文名稱(chēng)Neurocan
    中文名稱(chēng)神經(jīng)粘蛋白抗體
    別    名Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein; NCAN_HUMAN. 


    研究領(lǐng)域發(fā)育生物學(xué)  神經(jīng)生物學(xué)  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, )
    產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量140kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Neurocan:1185-1257/1257 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain. It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development. Neurocan expression in the brain is developmentally regulated. Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each. Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains. By virtue of their high expression at sites of neural damage and trauma, chondroitin sulfate proteoglycans, including neurocan, are thought to inhibit successful nerve regeneration. Alternative names: Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein.

    Function:
    May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

    Subcellular Location:
    Secreted.

    Tissue Specificity:
    Brain.

    Similarity:
    Belongs to the aggrecan/versican proteoglycan family.
    Contains 1 C-type lectin domain.
    Contains 2 EGF-like domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    Contains 2 Link domains.
    Contains 1 Sushi (CCP/SCR) domain.

    SWISS:
    P55066

    Gene ID:
    1463

    Database links:

    Entrez Gene: 1463 Human

    Entrez Gene: 58982 Rat

    Omim: 600826 Human

    SwissProt: O14594 Human

    SwissProt: P55067 Rat

    Unigene: 169047 Human

    Unigene: 10177 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology）
    神經(jīng)粘蛋白(Neurocan)是由神經(jīng)元分泌的特異性蛋白質(zhì),廣泛分布于神經(jīng)系統,可與神經(jīng)元細胞膜上特異性受體神經(jīng)粘附分子和神經(jīng)元膠質(zhì)細胞黏附分子結合,調節細胞連接,影響軸突生長(cháng).而在中樞神經(jīng)系統損傷后,Neurocan的表達增加,并抑制軸突生長(cháng).Neurocan在中樞神經(jīng)系統的形成和損傷后的修復都扮演著(zhù)重要的角色.


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