黑色素瘤相關(guān)抗原/黑色素-A抗體

產(chǎn)品貨號：

BN41473R
中文名稱(chēng)：

黑色素瘤相關(guān)抗原/黑色素-A抗體
英文名稱(chēng)：

Rabbit anti-Melan A Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN41473R-50ul

50ul

￥1486.00

交叉反應：Human 推薦應用：IHC-P,IHC-F,IF,ELISA
BN41473R-100ul

100ul

￥2360.00

交叉反應：Human 推薦應用：IHC-P,IHC-F,IF,ELISA
BN41473R-200ul

200ul

￥3490.00

交叉反應：Human 推薦應用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱(chēng)	Melan A
中文名稱(chēng)	黑色素瘤相關(guān)抗原/黑色素-A抗體
別名	Protein Melan-A; Antigen LB39 AA; MelanA; Melanoma HMB45; Antigen SK29 AA; Antigen SK29-AA; CMM 1; CMM; CMM1; Cutaneous Malignant Melanoma Dysplastic Nevus; DNS; Dysplastic Nevus Syndrome; FAMMM; MART1; melan A; Melan A protein; Melanoma antigen recognized by T-cells 1; MLM; Monophenol monooxygenase; Tumor rejection antigen AB; tyrosinase; Melanoma HMB45; Melanoma; Melan-A; MART-1; MAR1_HUMAN.
研究領(lǐng)域	腫瘤細胞生物免疫學(xué) 腫瘤細胞生物標志物
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Human,
產(chǎn)品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	13kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Melan-A:51-118/118
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis. Function: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. Subunit: Interacts with PMEL. Interacts with GPR143. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation. Tissue Specificity: Expression is restricted to melanoma and melanocyte cell lines and retina. Post-translational modifications: Acylated. SWISS: Q16655 Gene ID: 2315 Database links: Entrez Gene: 2315 Human Omim: 605513 Human SwissProt: Q16655 Human Unigene: 154069 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 信號中間體（Signaling Intermediates） MelanA/MART-1是分化腫瘤抗原類(lèi)別中具有代表性的成員，它表達于正常的黑素細胞和大多數原發(fā)及轉移的黑色素瘤中，故稱(chēng)：黑色素瘤相關(guān)抗原。