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    • 最近搜索：細胞培養 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>ChAT膽堿乙酰轉移酶抗體
    ChAT膽堿乙酰轉移酶抗體
    • 產(chǎn)品貨號：
      BN41470R
    • 中文名稱(chēng)：
      ChAT膽堿乙酰轉移酶抗體
    • 英文名稱(chēng)：
      Rabbit anti-ChAT Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN41470R-50ul

      50ul

      ￥1486.00

      交叉反應：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41470R-100ul

      100ul

      ￥2360.00

      交叉反應：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41470R-200ul

      200ul

      ￥3490.00

      交叉反應：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱(chēng)ChAT
    中文名稱(chēng)ChAT膽堿乙酰轉移酶抗體
    別    名Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN.  



    研究領(lǐng)域神經(jīng)生物學(xué)  Alzheimer's  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, )
    產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:200-800 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量82kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human ChAT:101-200/748 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010].

    Function:
    Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

    DISEASE:
    Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.

    Similarity:
    Belongs to the carnitine/choline acetyltransferase family.

    SWISS:
    P28329

    Gene ID:
    1103

    Database links:

    Entrez Gene: 1103 Human

    Entrez Gene: 12647 Mouse

    Entrez Gene: 290567 Rat

    Omim: 118490 Human

    SwissProt: P28329 Human

    SwissProt: Q03059 Mouse

    SwissProt: P32738 Rat

    Unigene: 302002 Human

    Unigene: 442817 Mouse

    Unigene: 45116 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    膽堿乙酰轉移酶是一種在神經(jīng)元胞體內合成的酶。當該轉移酶被合成以后，通過(guò)軸質(zhì)流動(dòng)方式轉移到神經(jīng)軸突末端。其功能是將乙酰輔酶A轉移到膽堿上，導致神經(jīng)遞質(zhì)乙酰膽堿的形成。膽堿能系統參與多種神經(jīng)功能。一些膽堿能神經(jīng)元的改變能導致阿爾茨海默病的發(fā)生。
    膽堿乙酰轉移酶通常被用來(lái)標記神經(jīng)元。


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