低密度脂蛋白受體的誘導降解蛋白抗體

產(chǎn)品貨號：

BN41398R
中文名稱(chēng)：

低密度脂蛋白受體的誘導降解蛋白抗體
英文名稱(chēng)：

Rabbit anti-MYLIP Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN41398R-100ul

100ul

￥2360.00

交叉反應：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,ELISA
BN41398R-200ul

200ul

￥3490.00

交叉反應：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱(chēng)	MYLIP
中文名稱(chēng)	低密度脂蛋白受體的誘導降解蛋白抗體
別名	BZF1; E3 ubiquitin protein ligase MYLIP; E3 ubiquitin-protein ligase MYLIP; Idol; Inducible degrader of the LDL-receptor; Idol; MIR; MYLIP; MYLIP_HUMAN; Myosin regulatory light chain interacting protein.
研究領(lǐng)域	心血管細胞生物信號轉導細胞周期蛋白細胞骨架表觀(guān)遺傳學(xué)
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	49kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human MYLIP:51-150/445
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. Subunit: Interacts with myosin regulatory light chain (MRLC) and TMEM4. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Autoubiquitinated. Similarity: Contains 1 FERM domain. Contains 1 RING-type zinc finger. SWISS: Q8WY64 Gene ID: 29116 Database links: Entrez Gene: 29116 Human Entrez Gene: 218203 Mouse Omim: 610082 Human SwissProt: Q8WY64 Human SwissProt: Q8BM54 Mouse Unigene: 484738 Human Unigene: 212855 Mouse Unigene: 481228 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.