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    • 最近搜索：細胞培養 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>MAS1癌基因抗體
    MAS1癌基因抗體
    • 產(chǎn)品貨號：
      BN41178R
    • 中文名稱(chēng)：
      MAS1癌基因抗體
    • 英文名稱(chēng)：
      Rabbit anti-MAS1 Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN41178R-100ul

      100ul

      ￥2360.00

      交叉反應：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig) 推薦應用：IHC-P,Flow-Cyt,ELISA

    • BN41178R-200ul

      200ul

      ￥3490.00

      交叉反應：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig) 推薦應用：IHC-P,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱(chēng)MAS1
    中文名稱(chēng)MAS1癌基因抗體
    別    名Mas-related G protein-coupled receptor A; MAS1 oncogene; MAS; MGRA; MAS_HUMAN.  


    研究領(lǐng)域腫瘤  免疫學(xué)  信號轉導  生長(cháng)因子和激素  細胞周期蛋白  轉錄調節因子  細胞表面分子  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
    產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量37kDa
    細胞定位細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human MAS1:51-150/325 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP binding proteins and share a conserved structural motif, which is described as a '7 transmembrane segment' following the prediction that these hydrophobic segments form membrane spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth regulating pathway to bring about oncogenic effects.

    Function:
    Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

    Subunit:
    Interacts with AGTR1 (Probable).

    Subcellular Location:
    Cell membrane; Multi-pass membrane protein.

    Similarity:
    Belongs to the G-protein coupled receptor 1 family.

    SWISS:
    P04201

    Gene ID:
    4142

    Database links:

    Entrez Gene: 4142 Human

    Omim: 165180 Human

    SwissProt: P04201 Human

    Unigene: 99900 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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