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    首頁(yè)>>免疫學(xué)>>一抗>>磷酸化RhoA蛋白抗體
    磷酸化RhoA蛋白抗體
    • 產(chǎn)品貨號：
      BN41075R
    • 中文名稱(chēng)：
      磷酸化RhoA蛋白抗體
    • 英文名稱(chēng)：
      Rabbit anti-Phospho-RhoA (Ser188) Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

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    • BN41075R-100ul

      100ul

      ￥2470.00

      交叉反應：Human,Rat(predicted:Mouse,Chicken,Dog,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱(chēng)Phospho-RhoA (Ser188)
    中文名稱(chēng)磷酸化RhoA蛋白抗體
    別    名RHOA(phospho S188); RhoA (phospho S188); RhoA protein; Aplysia ras related homolog 12; ARH 12; ARH12; ARHA; H 12; Oncogene RHO H12; Ras homolog gene family member A; RHO 12; Rho A; RHO H12; RHO12; RHOH 12; RHOH12; Small GTP binding protein Rho A; Small GTP binding protein RhoA; Transforming protein Rho A; Transforming protein RhoA.  



    產(chǎn)品類(lèi)型磷酸化抗體 
    研究領(lǐng)域腫瘤  信號轉導  G蛋白信號  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, Chicken, Dog, Cow, Sheep, )
    產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量21kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human RhoA around the phosphorylation site of Ser188:KK(p-S)GC 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

    Subunit:
    nteracts with RGNEF. Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation. Interacts with GNB2L1/RACK1; enhances RHOA activation. Interacts with PKP4; the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2.

    Similarity:
    Belongs to the small GTPase superfamily. Rho family.

    SWISS:
    P61586

    Gene ID:
    387

    Database links:

    Entrez Gene: 387 Human

    Entrez Gene: 11848 Mouse

    Entrez Gene: 117273 Rat

    Omim: 165390 Human

    SwissProt: P61586 Human

    SwissProt: Q9QUI0 Mouse

    SwissProt: P61589 Rat

    Unigene: 247077 Human

    Unigene: 757 Mouse

    Unigene: 107401 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    RhoA蛋白主要分布在細胞質(zhì)和細胞膜,RhoA蛋白家族是控制細胞骨架蛋白組合、調節基因表達等細胞活動(dòng)過(guò)程中的關(guān)鍵信號轉導成分。通常,RhoA通過(guò)激活其下游的Rho 連接激酶(Rho associated kinase,ROK)而起作用。在調節細胞骨架組建的過(guò)程中,RhoA與其作用對象均在胞質(zhì)內。


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