轉化生長(cháng)因子β調節蛋白1抗體

產(chǎn)品貨號：

BN41010R
中文名稱(chēng)：

轉化生長(cháng)因子β調節蛋白1抗體
英文名稱(chēng)：

Rabbit anti-TBRG1 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN41010R-100ul

100ul

￥2360.00

交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41010R-200ul

200ul

￥3490.00

交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱(chēng)	TBRG1
中文名稱(chēng)	轉化生長(cháng)因子β調節蛋白1抗體
別名	NIAM; Nuclear interactor of ARF and Mdm2; Transforming growth factor beta regulator 1; TBRG1; TBRG-1; TBRG 1; Transforming growth factor beta regulator 1.
研究領(lǐng)域	腫瘤細胞生物免疫學(xué) 染色質(zhì)和核信號細胞周期蛋白
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	45kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TBRG1:28-130/411
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Acts as a growth inhibitor. Can activate TP53/p53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. There are two isoforms. Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. Subunit: Interacts with CDKN2A and MDM2. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma. Post-translational modifications: Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation. Similarity: Belongs to the TBRG1 family. Contains 1 FYR C-terminal domain. Contains 1 FYR N-terminal domain. SWISS: Q3YBR2 Gene ID: 84897 Database links: Entrez Gene: 84897 Human Entrez Gene: 21376 Mouse Entrez Gene: 300521 Rat Omim: 610614 Human SwissProt: Q3YBR2 Human SwissProt: Q3UB74 Mouse SwissProt: Q5PQK8 Rat Unigene: 436410 Human Unigene: 28689 Mouse Unigene: 129282 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.