瞬時(shí)受體電位離子通道蛋白/M亞家族抗體

產(chǎn)品貨號：

BN40835R
中文名稱(chēng)：

瞬時(shí)受體電位離子通道蛋白/M亞家族抗體
英文名稱(chēng)：

Rabbit anti-TRPM2 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN40835R-100ul

100ul

￥2360.00

交叉反應：Human(predicted:Mouse,Rat,Horse) 推薦應用：ELISA
BN40835R-200ul

200ul

￥3490.00

交叉反應：Human(predicted:Mouse,Rat,Horse) 推薦應用：ELISA

產(chǎn)品描述

英文名稱(chēng)	TRPM2
中文名稱(chēng)	瞬時(shí)受體電位離子通道蛋白/M亞家族抗體
別名	EREG 1; EREG1; TRPM2_HUMAN; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTRPC2; NUDT9H; NUDT9L1; putative Ca2+ channel protein; transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; TRPC 7; TRPC7.
研究領(lǐng)域	免疫學(xué) 神經(jīng)生物學(xué) 通道蛋白
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Human, (predicted: Mouse, Rat, Horse, )
產(chǎn)品應用	WB=1:500-2000 ELISA=1:2000-5000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	165kDa
細胞定位	細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TRPM2:951-1050/1503 <Extracellular>
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death. Subunit: Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. Contains 1 nudix hydrolase domain. SWISS: O94759 Gene ID: 7226 Database links: Entrez Gene: 7226 Human Entrez Gene: 28240 Mouse Entrez Gene: 294329 Rat Omim: 603749 Human SwissProt: O94759 Human SwissProt: Q5KTC0 Mouse SwissProt: Q91YD4 Mouse SwissProt: Q5G856 Rat Unigene: 369759 Human Unigene: 276762 Mouse Unigene: 214495 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TRPM2 屬于瞬時(shí)受體電位離子通道蛋白家族的M亞家族，是一種非選擇性的陽(yáng)離子通道蛋白, 是離子通道蛋白參與了單核細胞的氧化應激應答反應，與老年性癡呆等神經(jīng)退行疾病的發(fā)生與發(fā)展有著(zhù)十分密切的聯(lián)系.