心臟和神經(jīng)嵴衍生蛋白2抗體

產(chǎn)品貨號：

BN40739R
中文名稱(chēng)：

心臟和神經(jīng)嵴衍生蛋白2抗體
英文名稱(chēng)：

Rabbit anti-HAND2 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN40739R-100ul

100ul

￥2360.00

交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用：WB
BN40739R-200ul

200ul

￥3490.00

交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用：WB

產(chǎn)品描述

英文名稱(chēng)	HAND2
中文名稱(chēng)	心臟和神經(jīng)嵴衍生蛋白2抗體
別名	DHAND 2; dHAND; DHAND2; Ehand 2; Ehand2; FLJ16260; HAND 2; Hand2; autonomic nervous system and neural crest derivatives-expressed protein 2; heart; Basic helix loop helix transcription factor HAND2; bHLHa26; Class A basic helix-loop-helix protein 26; Deciduum; Deciduum heart autonomic nervous system and neural crest derivatives expressed protein 2 antibody HAND2_HUMAN; Heart and neural crest derivatives expressed 2; Heart and neural crest derivatives expressed protein 2; heart and neural crest derivatives expressed transcript 2; Heart- and neural crest derivatives-expressed protein 2; Hed; Highly similar to dHAND M musculus; MGC125303; MGC125304; Th 2; Th2; Thing 2; Thing2.
研究領(lǐng)域	心血管細胞生物免疫學(xué) 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 表觀(guān)遺傳學(xué)
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應用	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	24kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human HAND2:141-217/217
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. Function: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Subcellular Location: Nucleus. Tissue Specificity: Heart. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: P61296 Gene ID: 9464 Database links: Entrez Gene: 9464 Human Entrez Gene: 15111 Mouse Entrez Gene: 64637 Rat Entrez Gene: 58150 Zebrafish Omim: 602407 Human SwissProt: Q90690 Chicken SwissProt: P61296 Human SwissProt: Q61039 Mouse SwissProt: P61295 Rat SwissProt: P57102 Zebrafish Unigene: 388245 Human Unigene: 261588 Mouse Unigene: 430844 Mouse Unigene: 36496 Rat Unigene: 41057 Rat Unigene: 81423 Zebrafish Unigene: 8328 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.