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    首頁(yè)>>免疫學(xué)>>一抗>>激活素受體2A抗體
    激活素受體2A抗體
    • 產(chǎn)品貨號：
      BN40737R
    • 中文名稱(chēng)：
      激活素受體2A抗體
    • 英文名稱(chēng)：
      Rabbit anti-ACVR2A Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN40737R-100ul

      100ul

      ￥2360.00

      交叉反應：Human,Mouse,Rat 推薦應用：WB

    • BN40737R-200ul

      200ul

      ￥3490.00

      交叉反應：Human,Mouse,Rat 推薦應用：WB

    產(chǎn)品描述

    英文名稱(chēng)ACVR2A
    中文名稱(chēng)激活素受體2A抗體
    別    名Activin receptor 2A; Activin receptor type 2A; ACTR 2; ACTR IIA; ACTR2; ActRIIa; Acvr 2; Acvr 2A; Acvr2; Acvr2a; OTTHUMP00000197918; ACVR2A; Activin receptor type-2A.  
    研究領(lǐng)域轉錄調節因子  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Human, Mouse, Rat, 
    產(chǎn)品應用WB=1:500-2000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量57kDa
    細胞定位細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from mouse ACVR2A:1-100/513 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. Activin has been suggested to be an autocrine/paracrine regulator in the human placenta. The presence of ACVR2 mRNA has been deomnstrated in human trophoblast cells and there is also evidence of expression of the gene in human brain and ovary.

    Function:
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

    Subunit:
    Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.

    Subcellular Location:
    Membrane; Single-pass type I membrane protein.

    Similarity:
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.

    SWISS:
    P27038

    Gene ID:
    11480

    Database links:

    Entrez Gene: 92 Human

    Entrez Gene: 11480 Mouse

    Entrez Gene: 29263 Rat

    Omim: 102581 Human

    SwissProt: P27037 Human

    SwissProt: P27038 Mouse

    SwissProt: P38444 Rat

    Unigene: 470174 Human

    Unigene: 314338 Mouse

    Unigene: 161783 Ra



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    激活素受體ⅡA- ARIP2a屬于A(yíng)RIP家族新成員，在腦組織、垂體、睪丸中表達較高，胰腺、卵巢組織中有表達。




















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