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    • 最近搜索：細胞培養 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>Rap1A抗體
    Rap1A抗體
    • 產(chǎn)品貨號：
      BN40734R
    • 中文名稱(chēng)：
      Rap1A抗體
    • 英文名稱(chēng)：
      Rabbit anti-RAP1A Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN40734R-100ul

      100ul

      ￥2360.00

      交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用：WB

    • BN40734R-200ul

      200ul

      ￥3490.00

      交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用：WB

    產(chǎn)品描述

    英文名稱(chēng)RAP1A
    中文名稱(chēng)Rap1A抗體
    別    名C21KG; RAP1; G 22K; G-22K; GTP binding protein smg p21A; GTP-binding protein smg p21A; KREV 1; KREV-1; KREV1; OTTHUMP00000013741; RAP 1A; RAP1; RAP1A; RAP1A member of RAS oncogene family; RAP1A_HUMAN; Ras related protein Krev 1; Ras related protein Rap 1A; RAS related protein RAP1A; Ras-related protein Krev-1; Ras-related protein Rap-1A; SMGP21; rap1a; RAS-related protein-1a precursor; Rap1A-retro2; RAP1A, member of RAS oncogene family.  
    研究領(lǐng)域細胞生物  免疫學(xué)  信號轉導  G蛋白信號  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
    產(chǎn)品應用WB=1:500-2000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量21kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human RAP1A:1-100/184 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

    Function:
    Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

    Subunit:
    Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain)

    Subcellular Location:
    Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions. Colocalized with RAPGEF2 in the perinuclear region.

    Similarity:
    Belongs to the small GTPase superfamily. Ras family.

    SWISS:
    P62834

    Gene ID:
    5906

    Database links:

    Entrez Gene: 5906 Human

    Entrez Gene: 109905 Mouse

    Entrez Gene: 295347 Rat

    Omim: 179520 Human

    SwissProt: P62834 Human

    SwissProt: P62835 Mouse

    SwissProt: P62836 Rat

    Unigene: 190334 Human

    Unigene: 458171 Mouse

    Unigene: 106321 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    RAP1A 是RAS癌基因家族成員，在調節細胞增生和粘附中有重要作用.經(jīng)研究發(fā)現,Rap1和它的調節子SPA-1在很多惡性腫瘤的發(fā)生、發(fā)展中起到一定的作用。定位于胞漿、胞膜。





















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