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    首頁(yè)>>免疫學(xué)>>一抗>>鋅轉運體8蛋白抗體
    鋅轉運體8蛋白抗體
    • 產(chǎn)品貨號：
      BN40708R
    • 中文名稱(chēng)：
      鋅轉運體8蛋白抗體
    • 英文名稱(chēng)：
      Rabbit anti-ZNT8 Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN40708R-100ul

      100ul

      ￥2360.00

      交叉反應：Rat(predicted:Human,Mouse) 推薦應用：IHC-P

    • BN40708R-200ul

      200ul

      ￥3490.00

      交叉反應：Rat(predicted:Human,Mouse) 推薦應用：IHC-P

    產(chǎn)品描述

    英文名稱(chēng)ZNT8
    中文名稱(chēng)鋅轉運體8蛋白抗體
    別    名SLC30A8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8; Zinc transporter 8; zinc transporter ZnT-8; ZnT-8; ZNT 8; ZNT8_HUMAN.  
    研究領(lǐng)域細胞生物  免疫學(xué)  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Rat,  (predicted: Human, Mouse, )
    產(chǎn)品應用IHC-P=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量41kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human ZNT8:1-100/369 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹ZNT8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].

    Function:
    Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells

    Subunit:
    Homodimer (By similarity).

    Subcellular Location:
    Cell membrane; Multi-pass membrane protein (Probable). Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein (Probable). Note=Associated with insulin and glucagon secretory granules (By similarity).

    Tissue Specificity:
    In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.

    Similarity:
    Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.

    SWISS:
    Q8IWU4

    Gene ID:
    169026

    Database links:

    Entrez Gene: 169026 Human

    Omim: 611145 Human

    SwissProt: Q8IWU4 Human

    Unigene: 532270 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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