鈉離子/氫離子交換蛋白3抗體

產(chǎn)品貨號：

BN40706R
中文名稱(chēng)：

鈉離子/氫離子交換蛋白3抗體
英文名稱(chēng)：

Rabbit anti-hydrogen exchanger 3 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN40706R-100ul

100ul

￥2360.00

交叉反應：Human(predicted:Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB
BN40706R-200ul

200ul

￥3490.00

交叉反應：Human(predicted:Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB

產(chǎn)品描述

英文名稱(chēng)	hydrogen exchanger 3
中文名稱(chēng)	鈉離子/氫離子交換蛋白3抗體
別名	Na(+)/H(+) exchanger 3; NHE 3; NHE-3; NHE3; SL9A3_HUMAN; SLC9A 3; Sodium; Slc9a3; Sodium/hydrogen exchanger 3; Sodium/hydrogen exchanger, apical epithelial; Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; Solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3; MGC126718; MGC126720.
研究領(lǐng)域	腫瘤細胞生物信號轉導通道蛋白細胞膜蛋白
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Human, (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	93kDa
細胞定位	細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human hydrogen exchanger 3 :451-550/834 <Cytoplasmic>
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells. Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Subunit: Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels Subcellular Location: Membrane. In intestinal epithelial cells, localizes to the ileal brush border. Post-translational modifications: Phosphorylated by PKA, which inhibits activity. Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. SWISS: P48764 Gene ID: 6550 Database links: Entrez Gene: 6550 Human Entrez Gene: 24784 Rat Omim: 182307 Human SwissProt: P48764 Human SwissProt: P26433 Rat Unigene: 658120 Human Unigene: 9706 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.