激肽釋放酶9抗體（舒血管素9）

產(chǎn)品貨號：

BN40571R
中文名稱(chēng)：

激肽釋放酶9抗體（舒血管素9）
英文名稱(chēng)：

Rabbit anti-KLK9 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN40571R-100ul

100ul

￥2360.00

交叉反應：Mouse(predicted:Human,Rat,Horse) 推薦應用：IHC-P,IHC-F,IF,ELISA
BN40571R-200ul

200ul

￥3490.00

交叉反應：Mouse(predicted:Human,Rat,Horse) 推薦應用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱(chēng)	KLK9
中文名稱(chēng)	激肽釋放酶9抗體（舒血管素9）
別名	Kallikrein 8; Kallikrein 9; Kallikrein L3; Kallikrein Like 3; Kallikrein like protein 3; kallikrein related peptidase 9; Kallikrein-9; Kallikrein-like protein 3; Kallikrein8; Kallikrein9; KLK 8; KLK 9; KLK L3; KLK-L3; KLK8; KLK9; KLK9_HUMAN; KLKL 3; KLKL3.
研究領(lǐng)域	腫瘤細胞生物信號轉導激酶和磷酸酶細胞骨架細胞外基質(zhì)
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Mouse, (predicted: Human, Rat, Horse, )
產(chǎn)品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	26kDa
細胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human KLK9:51-150/250
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Kallikrein 9, also known as Kallikrein-Like 3 (KLK-L3), is a chymotrypsin-like serine proteinase. Kallikrein 9 was discovered as the locus for kallikreins on chromosome 19 was more fully mapped and found by similarity to the other tissue kallikreins. Kallikrein 9 has been found in the ovary, thymus, testis, prostate, skin, breast and neuronal tissues and is made by many cell lines in culture. Kallikrein 9 levels in breast cancer and uterine cancer patients have been reported to drop as the disease progresses, thus hK9 might be considered a favorable prognostic marker. Different splice variants of hK9 have been reported, although it is not yet known if they produce functional proteins. The full length Kallikrein 9 encodes for a 250 amino acid protein, with a predicted mass of 27.5 kDa and a pI of 7.53. The 234 amino acid form predicts a protein of 26 kDa with a pI of 9.76 and this quite basic pI might give the shorter form a very different function or localization. The shorter sequence also diverges before the catalytic serine residue, making it unlikely to be proteolytically active. Pre-pro-kallikrein 9 has the 17 amino acid signal sequence is removed before secretion, and the Pro-kallikrein 9 is activated to Kallikrein 9 by removal of the 5 amino acid propeptide domain. Subcellular Location: Secreted (Probable). Tissue Specificity: Skin, thymus, trachea, cerebellum and spinal cord. Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. SWISS: Q9UKQ9 Gene ID: 284366 Database links: Entrez Gene: 284366 Human Omim: 605504 Human SwissProt: Q9UKQ9 Human Unigene: 448942 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. KLK9目前認為是卵巢癌宮頸癌子宮內膜癌等其他腫瘤,很有意義的標志物。激肽釋放酶KLK是激肽系統的主要限速酶，它是一組存在于多數組織和體液中的絲氨酸蛋白酶，是一種肽鏈內切酶。KLK又稱(chēng)血管舒緩素，包括15個(gè)家族成員。在不同的組織中廣泛表達,具有蛋白水解酶的活性。它特異性的在碳末端切割底物肽，可裂解激肽原釋放具有活性的激肽，由激肽發(fā)揮對心血管系統及腎臟功能的調節作用。組織KLK是一個(gè)大的基因家族，主要分布在肺、腎、血管、腦、腎上腺組織，為一種中等大小的糖蛋白。