生長(cháng)抑制因子基因1抗體

產(chǎn)品貨號：

BN40399R
中文名稱(chēng)：

生長(cháng)抑制因子基因1抗體
英文名稱(chēng)：

Rabbit anti-ING1 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN40399R-100ul

100ul

￥2360.00

交叉反應：Mouse(predicted:Human,Rat) 推薦應用：WB,ELISA
BN40399R-200ul

200ul

￥3490.00

交叉反應：Mouse(predicted:Human,Rat) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱(chēng)	ING1
中文名稱(chēng)	生長(cháng)抑制因子基因1抗體
別名	ING1_HUMAN; Inhibitor of growth protein 1; inhibitor of growth gene 1; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds; ING 1; Inhibitor of growth 1; Inhibitor of growth family member 1; Inhibitor of growth protein 1; p24ING1c; p33 ING1; p33ING1; p33ING1b; p47ING1a; Tumor suppressor ING 1; Tumor suppressor ING1.
研究領(lǐng)域	腫瘤細胞生物信號轉導細胞凋亡細胞周期蛋白轉錄調節因子
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Mouse, (predicted: Human, Rat, )
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	46kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human inhibitor of growth gene 1:301-422/422
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]. Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Subcellular Location: Nucleus. Tissue Specificity: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. DISEASE: Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck. Similarity: Belongs to the ING family. Contains 1 PHD-type zinc finger. SWISS: Q9UK53 Gene ID: 3621 Database links: Entrez Gene: 3621 Human Entrez Gene: 26356 Mouse Entrez Gene: 306626 Rat GenBank: NP_937862 Human Omim: 601566 Human SwissProt: Q9UK53 Human SwissProt: Q9QXV3 Mouse Unigene: 46700 Human Unigene: 508725 Human Unigene: 25709 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 腫瘤的發(fā)生是一個(gè)多基因參與,多步驟發(fā)生的復雜過(guò)程，抑癌基因的功能失活與癌基因的激活為其主要原因之一。 ING1基因是近期發(fā)現的抑癌基因，研究發(fā)現，它的過(guò)表達可抑制細胞生長(cháng)、增殖,促進(jìn)細胞凋亡，它的低表達與腫瘤的發(fā)生、發(fā)展有關(guān)。ING1正常時(shí)定位于胞核，發(fā)揮其誘導凋亡和調控細胞周期的作用，當其易位于胞質(zhì)時(shí)上述作用逐步減弱或消失，在腫瘤發(fā)生時(shí)，多位于胞漿。