紅細胞分化相關(guān)基因蛋白抗體

產(chǎn)品貨號：

BN40360R
中文名稱(chēng)：

紅細胞分化相關(guān)基因蛋白抗體
英文名稱(chēng)：

Rabbit anti-Hemogen Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN40360R-100ul

100ul

￥2360.00

交叉反應：nan(predicted:Human) 推薦應用：WB,ELISA
BN40360R-200ul

200ul

￥3490.00

交叉反應：nan(predicted:Human) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱(chēng)	Hemogen
中文名稱(chēng)	紅細胞分化相關(guān)基因蛋白抗體
別名	EDAG; EDAG-1; Erythroid differentiation-associated gene protein; HEMGN; HEMGN_HUMAN; Hemogen; Hemopoietic gene protein; Negative differentiation regulator protein.
研究領(lǐng)域	腫瘤細胞生物免疫學(xué) 細胞分化
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	(predicted: Human, )
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	55kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Hemogen/EDAG:51-150/484
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Hemogen is a 484 amino acid protein encoded by the human gene HEMGN. Hemogen is a nuclear protein that is expressed in hematopoietic precursor cells and can be detected in CD34+ and K-562 leukemia cell line. It is also expressed in bone marrow, testis, thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. Hemogen is down-regulated during megakaryocytic differentiation of K-562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). It can be up-regulated in normal PBMCs by mitogens. Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). Subcellular Location: Nucleus. Tissue Specificity: Expressed in fetal liver, kidney and brain. Expressed in hematopoietic precursor cells (at protein level). Detected in CD34+ and K562 leukemia cell line (at protein level). Expressed in bone marrow, testis, thymus. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. SWISS: Q9BXL5 Gene ID: 55363 Database links: Entrez Gene: 55363 Human Omim: 610715 Human SwissProt: Q9BXL5 Human Unigene: 176626 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.