環(huán)指蛋白111抗體

產(chǎn)品貨號：

BN40272R
中文名稱(chēng)：

環(huán)指蛋白111抗體
英文名稱(chēng)：

Rabbit anti-RNF111 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規格

售價(jià)

備注
BN40272R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
BN40272R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱(chēng)	RNF111
中文名稱(chēng)	環(huán)指蛋白111抗體
別名	ARK; Arkadia; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; E3 ubiquitin protein ligase Arkadia; FLJ38008; Ring finger protein 111; RNF 111; RN111_HUMAN.
研究領(lǐng)域	細胞生物免疫學(xué) 信號轉導生長(cháng)因子和激素泛素
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Dog, Cow, Rabbit, Sheep, )
產(chǎn)品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	109kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human RNF111:851-950/994
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] Function: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Subunit: Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7. Interacts (via SIM domains) with SUMO1 and SUMO2. Subcellular Location: Cytoplasmic and Nuclear Tissue Specificity: Broadly expressed. Similarity: Contains 1 RING-type zinc finger. SWISS: Q6ZNA4 Gene ID: 54778 Database links: Entrez Gene: 54778 Human Omim: 605840 Human SwissProt: Q6ZNA4 Human Unigene: 404423 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications