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    • 最近搜索：細胞培養 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>谷氨酸脫羧酶-65抗體(C端）
    谷氨酸脫羧酶-65抗體(C端）
    • 產(chǎn)品貨號：
      BN40213R
    • 中文名稱(chēng)：
      谷氨酸脫羧酶-65抗體(C端）
    • 英文名稱(chēng)：
      Rabbit anti-GAD65 Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

      備注

    • BN40213R-100ul

      100ul

      ￥2360.00

      交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow) 推薦應用：WB,ICC,Flow-Cyt,ELISA

    • BN40213R-200ul

      200ul

      ￥3490.00

      交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow) 推薦應用：WB,ICC,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱(chēng)GAD65
    中文名稱(chēng)谷氨酸脫羧酶-65抗體(C端）
    別    名65 kDa glutamic acid decarboxylase; DCE 2; DCE2; GAD 2; GAD 65; GAD-2; GAD-65;GAD 65, GAD2; Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa); Glutamate Decarboxylase 2; Glutamate Decarboxylase 65; Glutamate decarboxylase 65 kDa isoform; Glutamic Acid Decarboxylase 2; Glutamic Acid Decarboxylase 65.  



    研究領(lǐng)域神經(jīng)生物學(xué)  新陳代謝  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, )
    產(chǎn)品應用ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量65kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human GAD65:501-585/585 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

    Function:
    Catalyzes the production of GABA.

    Subunit:
    Homodimer.

    Subcellular Location:
    Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.

    Post-translational modifications:
    Phosphorylated; which does not affect kinetic parameters or subcellular location.
    Palmitoylated; which is required for presynaptic clustering.

    Similarity:
    Belongs to the group II decarboxylase family.

    SWISS:
    Q05329

    Gene ID:
    2572

    Database links:

    Entrez Gene: 2572 Human

    Entrez Gene: 14417 Mouse

    Entrez Gene: 24380 Rat

    Omim: 138275 Human

    SwissProt: Q05329 Human

    SwissProt: Q5VZ29 Human

    SwissProt: Q5VZ30 Human

    SwissProt: P48320 Mouse

    SwissProt: Q548L4 Mouse

    SwissProt: Q05683 Rat

    Unigene: 231829 Human

    Unigene: 4784 Mouse

    Unigene: 29951 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    谷氨酸脫羧酶-65用于I II型糖尿病研究的很重要的蛋白。


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