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    首頁(yè)>>免疫學(xué)>>一抗>>β2-微球蛋白抗體
    β2-微球蛋白抗體
    • 產(chǎn)品貨號：
      BN40212R
    • 中文名稱(chēng)：
      β2-微球蛋白抗體
    • 英文名稱(chēng)：
      Rabbit anti-beta 2 Microglobulin Polyclonal antibody
    • 品牌：
      Biorigin

    • 貨號

      產(chǎn)品規格

      售價(jià)

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    • BN40212R-100ul

      100ul

      ￥2360.00

      交叉反應：Human 推薦應用：WB,ELISA

    • BN40212R-200ul

      200ul

      ￥3490.00

      交叉反應：Human 推薦應用：WB,ELISA

    產(chǎn)品描述

    英文名稱(chēng)beta 2 Microglobulin
    中文名稱(chēng)β2-微球蛋白抗體
    別    名B2M; Beta-2-MG; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta-2 microglobin; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; CDABP0092.  
    研究領(lǐng)域細胞生物  免疫學(xué)  淋巴細胞  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應Human, 
    產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量13/27kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原Recombinant human Beta-2-Microglobulin protein: 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].

    Function:
    Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

    Subunit:
    Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.

    Subcellular Location:
    Secreted. Note=Detected in serum and urine.

    Post-translational modifications:
    Glycation of Ile-21 is observed in long-term hemodialysis patients.

    DISEASE:
    Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

    Similarity:
    Belongs to the beta-2-microglobulin family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

    SWISS:
    P61769

    Gene ID:
    567

    Database links:

    Entrez Gene: 567 Human

    Entrez Gene: 12010 Mouse

    Entrez Gene: 24223 Rat

    Omim: 109700 Human

    SwissProt: P61769 Human

    SwissProt: P01887 Mouse

    SwissProt: P07151 Rat

    Unigene: 534255 Human

    Unigene: 702947 Human

    Unigene: 163 Mouse

    Unigene: 1868 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    小鼠抗人β2微球蛋白在中樞神經(jīng)系統感染、腫瘤及全身性自身免疫性疾病患者腦脊液中，會(huì )出現β


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